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The pre-dosed oral format removes the handling steps required by other presentations and simplifies study design wherever an oral route of exposure is preferred
64 Microbial metabolite axes: Intrahepatic signal decoding from bile acids, SCFAs to tryptophan derivatives Bile acid metabolism remodeling and intrahepatic signal regulation Gut microbes, through key enzymes they encode, such as BSH and 7-dehydroxylase, deconjugate and dehydroxylate host primary bile acids to generate secondary bile acids, thereby profoundly remodeling the composition and signaling function of the bile acid pool
